Total sleep deprivation alters endothelial function in rats: a nonsympathetic mechanism.

ABSTRACT:

Study objectives

Sleep loss is suspected to induce endothelial dysfunction, a key factor in cardiovascular risk. We examined whether sympathetic activity is involved in the endothelial dysfunction caused by total sleep deprivation (TSD).

Design

TWO GROUPS: TSD (24-h wakefulness), using slowly rotating wheels, and wheel control (WC).

Participants

Seven-month-old male Wistar rats.

Interventions

Pharmacological sympathectomy (reserpine, 5 mg/kg, intraperitoneal), nitric oxide synthase (NOS) inhibition (N (G)-nitro-L-arginine, 20 mg/kg, intraperitoneally 30 min before experiment) and cyclooxygenase (COX) inhibition (indomethacin, 5 mg/kg, intraperitoneally 30 min before experiment).

Measurements and results

In protocol 1, changes in heart rate (HR) and blood

SUBMITTER: Sauvet F 

PROVIDER: S-EPMC3920311 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature