Residual effects of low-dose sublingual zolpidem on highway driving performance the morning after middle-of-the-night use.

ABSTRACT:

Study objective

To evaluate next-morning driving performance after middle-of-the-night use of zolpidem 3.5 mg in a buffered sublingual formulation (ZST).

Design

Single-center, four-period, randomized, double-blind, placebo-controlled, crossover study.

Setting

Maastricht University, The Netherlands.

Participants

Forty healthy volunteers (20 females).

Interventions

Single dose of ZST administered in the middle of the night at 3 and 4 h before driving, zopiclone 7.5 mg at bedtime 9 h before driving, and placebo.

Measurements

Performance in a 100-km standardized highway driving test in normal traffic measuring standard deviation of lateral position (SDLP) - an index of weaving. Drug-placebo changes in SDLP > 2.5 cm were considered to reflect clinicall

SUBMITTER: Vermeeren A 

PROVIDER: S-EPMC3920314 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature