Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants.

ABSTRACT: Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and its prevalence is expected to increase in the coming years. CAD events are caused by the interplay of genetic and environmental factors, the effects of which are mainly mediated through cardiovascular risk factors. The techniques used to study the genetic basis of these diseases have evolved from linkage studies to candidate gene studies and genome-wide association studies. Linkage studies have been able to identify genetic variants associated with monogenic diseases, whereas genome-wide association studies have been more successful in determining genetic variants associated with complex diseases. Currently, genome-wide association studies have identified approximately 40 loci that explain 6% of the h

SUBMITTER: Sayols-Baixeras S 

PROVIDER: S-EPMC3920464 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature