Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging.

ABSTRACT: Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd³⁺ complexes at very high loadings (15.5-28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption measurements, thermogravimetric analysis (TGA), direct current plasma (DCP) spectroscopy, and powder X-ray diffraction (PXRD). The magnetic resonance (MR) relaxivities of these contrast agents were determined using a 3 T MR scanner. The r₁ relaxivities of these nanoparticles range from 4.1 to 8.4 mM^-1s^-1 on a per Gd basis. Additionally, the MSN particles were functionalized with an organic fluoro

SUBMITTER: Taylor-Pashow KM 

PROVIDER: S-EPMC3920552 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature