Human μ Opioid Receptor Models with Evaluation of the Accuracy Using the Crystal Structure of the Murine μ Opioid Receptor.

ABSTRACT: Models of the human μ opioid receptor were constructed using available G-protein-coupled receptor (GPCR) structures using homology (comparative) modeling techniques. The recent publication of a high-resolution crystal structure of a construct based on the murine μ opioid receptor offers a unique opportunity to evaluate the reliability of the homology models and test the relevance of introducing more templates (known structures) to increase the accuracy of the comparative models. In the first model two templates were used: the β₂ adrenergic and bovine rhodopsin receptors. For the second model, four templates were utilized: the β₂ adrenergic, bovine rhodopsin, β₁ adrenergic, and A_2A adenosine receptors. Including additional templates improved the a

SUBMITTER: Perez-Aguilar JM 

PROVIDER: S-EPMC3920553 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature