Heart rate variability is a predictor of mortality in chronic kidney disease: a report from the CRIC Study.

ABSTRACT:

Background/aims

Low heart rate variability (HRV) is a risk factor for adverse outcomes in the general population. We aimed to determine the factors associated with HRV and evaluate the association between low HRV and clinical outcomes in patients with chronic kidney disease (CKD).

Methods

A 10-second electrocardiogram was obtained at baseline in the Chronic Renal Insufficiency Cohort (CRIC) Study. HRV was measured by the standard deviation of all R-R intervals (SDNN) and the root mean square of successive differences between R-R intervals (RMSSD).

Results

In 3,245 CRIC participants with available baseline SDNN and RMSSD, lower HRV was associated with older age, lack of exercise, heart failure, elevated phosphorus and hemoglobin A1c, and low estimated glomerular filtra

SUBMITTER: Drawz PE 

PROVIDER: S-EPMC3920657 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature