OCT minimum intensity as a predictor of geographic atrophy enlargement.

ABSTRACT:

Purpose

We determined whether the minimum intensity (MI) of the optical coherence tomography (OCT) A-scans within the retina can predict locations of growth at the margin of geographic atrophy (GA) and the growth rate outside the margin.

Methods

The OCT scans were analyzed at baseline and 52 weeks. Expert graders manually segmented OCT images of GA. The 52-week follow-up scans were registered to the baseline scan coordinates for comparison. The OCT MI values were studied within a 180-μm margin around the boundary of GA at baseline. Baseline MI values were compared in areas of progression and nonprogression of the GA, and sensitivity and specificity were assessed for prediction of growth at the margin. Average MI values in the margins were compared to overall growth rates to

SUBMITTER: Stetson PF 

PROVIDER: S-EPMC3920825 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature