Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.

ABSTRACT: Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed by reactions from serine synthesis, one-carbon (folate) metabolism and the glycine cleavage system (SOG pathway). Here we show that the SOG pathway is upregulated at the level of gene expression in a subset of human tumors and that its level of expression correlates with gene signatures of cell proliferation and Myc target activation. We have also estimated the SOG pathway metabolic flux in the NCI60 tumor-derived cell lines, using previously reported exchange fluxes and a personalized model of cell metabolism. We find that the estimated rat

SUBMITTER: Tedeschi PM 

PROVIDER: S-EPMC3920946 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature