Fecal immunochemical test accuracy in average-risk colorectal cancer screening.

ABSTRACT:

Aim

To assess the fecal immunochemical test (FIT) accuracy for colorectal cancer (CRC) and advanced neoplasia (AN) detection in CRC screening.

Methods

We performed a multicentric, prospective, double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy. Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample (FIT1) and the highest level of both samples (FITmax) using the OC-sensor™. Areas under the curve (AUC) for CRC and AN were calculated. The best FIT1 and FITmax cut-off values for CRC were determined. At this threshold, number needed to scope (NNS) to detect a CRC and an AN and the cost per lesion detected were calculated.

Results

About 779 individuals were in

SUBMITTER: Hernandez V 

PROVIDER: S-EPMC3921527 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature