Aortic stiffness is associated with left ventricular diastolic dysfunction in systemic lupus erythematosus: a controlled transesophageal echocardiographic study.

ABSTRACT:

Background

Aortic stiffness and left ventricular (LV) diastolic dysfunction are common and associated with increased morbidity and mortality in systemic lupus erythematosus (SLE).

Hypothesis

In SLE, aortic stiffness and LV diastolic dysfunction may be associated.

Methods

This 6-year-duration, cross-sectional, and controlled study was conducted in 76 SLE patients (69 women; mean age, 37 ± 12 years) and 26 age- and sex-matched healthy controls. All subjects underwent clinical and laboratory evaluations and transesophageal echocardiography (TEE) to assess LV diastolic function and stiffness of the descending thoracic aorta using the pressure-strain elastic modulus (PSEM). To validate results using PSEM, aortic strain, stiffness, and distensibility were assessed.

Resul

SUBMITTER: Roldan CA 

PROVIDER: S-EPMC3921688 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature