Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women.

ABSTRACT:

Background

Persistent high-risk (HR) human papillomavirus (HPV) infection and increased HR-HPV viral load are associated with the development of cancer. This study investigated the effect of human immunodeficiency virus (HIV) co-infection, HIV viral load and CD4 count on the HR-HPV viral load; and also investigated the predictors of cervical abnormalities.

Methods

Participants were 292 HIV-negative and 258 HIV-positive women. HR-HPV viral loads in cervical cells were determined by the real-time polymerase chain reaction.

Results

HIV-positive women had a significantly higher viral load for combined alpha-9 HPV species compared to HIV-negative women (median 3.9 copies per cell compared to 0.63 copies per cell, P = 0.022). This was not observed for individual HPV types.

SUBMITTER: Mbulawa ZZ 

PROVIDER: S-EPMC3922074 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature