Genotype-environment interactions for quantitative traits in Korea Associated Resource (KARE) cohorts.

ABSTRACT:

Background

Due to the lack of statistical power and confounding effects of population structure in human population data, genotype-environment interaction studies have not yielded promising results and have provided only limited knowledge for exploring how genotype and environmental factors interact to in their influence onto risk.

Results

We analyzed 49 human quantitative traits in 7,170 unrelated Korean individuals on 326,262 autosomal single nucleotide polymorphisms (SNPs) collected from the KARE (Korean Association Resource) project, and we estimated the statistically significant proportion of variance that could be explained by genotype-area interactions in the supra-iliac skinfold thickness trait (hGE2 = 0.269 and P = 0.00032), which is related to abdominal obesity. Da

SUBMITTER: Kim J 

PROVIDER: S-EPMC3922112 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature