Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances.

ABSTRACT: Genotype scores that predict relevant clinical outcomes may detect other disease features and help direct prevention efforts. We report data that validate a previously established v1.0 smoking cessation quit success genotype score and describe striking differences in the score in individuals who display differing developmental trajectories of use of common addictive substances. In a cessation study, v1.0 genotype scores predicted ability to quit with P=0.00056 and area under receiver-operating characteristic curve 0.66. About 43% vs 13% quit in the upper vs lower genotype score terciles. Latent class growth analyses of a developmentally assessed sample identified three latent classes based on substance use. Higher v1.0 scores were associated with (a) higher probabilities of participant mem

SUBMITTER: Uhl GR 

PROVIDER: S-EPMC3922203 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature