Association of TNFSF15 polymorphism with irritable bowel syndrome.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting more than 10% of the general population worldwide. Although a genetic component is suspected, unambiguous susceptibility genes have so far not been identified. This study tested the hypothesis that genes contributing to epithelial barrier integrity, control of mucosal immune responses and interactions with bacteria in the gut are associated with IBS.

Methods

Single nucleotide polymorphisms (SNPs) corresponding to top signals of association with Crohn's disease at 30 known susceptibility loci were tested for their effect on IBS risk in 1992 individuals from two independent case-control cohorts from Sweden and the USA. Association tests included a conservative Bonferroni correctio

SUBMITTER: Zucchelli M 

PROVIDER: S-EPMC3922294 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature