Single-step Radiosyntheses of '¹⁸F-Labeled Click Synthons' from Azide-functionalized Diaryliodonium Salts.

ABSTRACT: Positron emission tomography (PET) is an increasingly important biomedical imaging technique that relies on the development of radiotracers labeled with positron-emitters to achieve biochemical specificity. Fluorine-18 (t_1/2 = 109.7 min) is an attractive positron-emitting radiolabel for organic radiotracers, primarily because of its longer half-life and greater availability relative to those for the main alternative, carbon-11 (t_1/2 = 20.4 min). Rapid simple methods are sought for labeling prospective PET radiotracers with fluorine-18 from cyclotron-produced aqueous [¹⁸F]fluoride ion, which must often be converted first into a suitably reactive labeling synthon for use in a subsequent labelling reaction. Use of ¹⁸F-labeled synthons

SUBMITTER: Joong-Hyun C 

PROVIDER: S-EPMC3922306 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature