Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression.

ABSTRACT:

Objective

This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk.

Method

The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software.

Results

Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might i

SUBMITTER: Wang Q 

PROVIDER: S-EPMC3922770 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature