Candidate gene approach for parasite resistance in sheep--variation in immune pathway genes and association with fecal egg count.

ABSTRACT: Sheep chromosome 3 (Oar3) has the largest number of QTLs reported to be significantly associated with resistance to gastro-intestinal nematodes. This study aimed to identify single nucleotide polymorphisms (SNPs) within candidate genes located in sheep chromosome 3 as well as genes involved in major immune pathways. A total of 41 SNPs were identified across 38 candidate genes in a panel of unrelated sheep and genotyped in 713 animals belonging to 22 breeds across Asia, Europe and South America. The variations and evolution of immune pathway genes were assessed in sheep populations across these macro-environmental regions that significantly differ in the diversity and load of pathogens. The mean minor allele frequency (MAF) did not vary between Asian and European sheep reflecting the absenc

SUBMITTER: Periasamy K 

PROVIDER: S-EPMC3922807 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature