Tertiary structure prediction and identification of druggable pocket in the cancer biomarker - Osteopontin-c.

ABSTRACT:

Background

Osteopontin (Eta, secreted sialoprotein 1, opn) is secreted from different cell types including cancer cells. Three splice variant forms namely osteopontin-a, osteopontin-b and osteopontin-c have been identified. The main astonishing feature is that osteopontin-c is found to be elevated in almost all types of cancer cells. This was the vital point to consider it for sequence analysis and structure predictions which provide ample chances for prognostic, therapeutic and preventive cancer research.

Methods

Osteopontin-c gene sequence was determined from Breast Cancer sample and was translated to protein sequence. It was then analyzed using various software and web tools for binding pockets, docking and druggability analysis. Due to the lack of homological templates,

SUBMITTER: Sivakumar S 

PROVIDER: S-EPMC3922830 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature