A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population.

ABSTRACT:

Background

Uric acid (UA) is a complex phenotype influenced by both genetic and environmental factors as well as their interactions. Current genome-wide association studies (GWASs) have identified a variety of genetic determinants of UA in Europeans; however, such studies in Asians, especially in Chinese populations remain limited.

Methods

A two-stage GWAS was performed to identify single nucleotide polymorphisms (SNPs) that were associated with serum uric acid (UA) in a Chinese population of 12,281 participants (GWAS discovery stage included 1452 participants from the Dongfeng-Tongji cohort (DFTJ-cohort) and 1999 participants from the Fangchenggang Area Male Health and Examination Survey (FAMHES). The validation stage included another independent 8830 individuals from the D

SUBMITTER: Yang B 

PROVIDER: S-EPMC3923000 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature