First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase.

ABSTRACT: We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

SUBMITTER: Riley AM 

PROVIDER: S-EPMC3923271 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature