Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules.

ABSTRACT: Glioblastomas (GBMs) are the most common and malignant primary brain tumors and are aggressively treated with surgery, chemotherapy, and radiotherapy. Despite this treatment, recurrence is inevitable and survival has improved minimally over the last 50 years. Recent studies have suggested that GBMs exhibit both heterogeneity and instability of differentiation states and varying sensitivities of these states to radiation. Here, we employed an iterative combined theoretical and experimental strategy that takes into account tumor cellular heterogeneity and dynamically acquired radioresistance to predict the effectiveness of different radiation schedules. Using this model, we identified two delivery schedules predicted to significantly improve efficacy by taking advantage of the dynamic instab

SUBMITTER: Leder K 

PROVIDER: S-EPMC3923371 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature