Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: a randomized controlled trial.

ABSTRACT:

Objective

To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants.

Patients and methods

Forty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011.

Results

In mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose,

SUBMITTER: Oberhelman SS 

PROVIDER: S-EPMC3923377 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature