Subclinical hypothyroidism and the risk of coronary heart disease and mortality.

ABSTRACT:

Context

Data regarding the association between subclinical hypothyroidism and cardiovascular disease outcomes are conflicting among large prospective cohort studies. This might reflect differences in participants' age, sex, thyroid-stimulating hormone (TSH) levels, or preexisting cardiovascular disease.

Objective

To assess the risks of coronary heart disease (CHD) and total mortality for adults with subclinical hypothyroidism.

Data sources and study selection

The databases of MEDLINE and EMBASE (1950 to May 31, 2010) were searched without language restrictions for prospective cohort studies with baseline thyroid function and subsequent CHD events, CHD mortality, and total mortality. The reference lists of retrieved articles also were searched.

Data extraction

I

SUBMITTER: Rodondi N 

PROVIDER: S-EPMC3923470 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature