Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253.

ABSTRACT:

Background

Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients.

Methods

An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic evaluation (SDE) for TB with standard of care (SOC). SOC evaluations included TB symptom review (current cough, fever, night sweats and/or weight loss), sputum Ziehl-Neelsen staining and chest radiography. SDE screening added extended clinical signs and symptoms and fluorescent microscopy (FM). All participants underwent all evaluations. Mycobacterium tuberculosis on sputum culture was the primary outcome.

Results

A total of 801 participants were enrolled from Botswana, Malawi, South Africa, Zimbabwe, India, Peru and Brazi

SUBMITTER: Swindells S 

PROVIDER: S-EPMC3923622 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature