Quantifying the interfractional displacement of the gastroesophageal junction during radiation therapy for esophageal cancer.

ABSTRACT:

Purpose

Accounting for interfractional changes in tumor location improves the accuracy of radiation treatment delivery. The purpose of this study was to quantify the interfractional displacement of the gastroesophageal junction (GEJ) based on standard treatment setup in patients with esophageal cancer undergoing radiation therapy.

Methods and materials

Free-breathing four-dimensional computed tomography (4D-CT) datasets were acquired weekly from 22 patients during treatment for esophageal adenocarcinoma. Scans were registered to baseline (simulation) 4D-CT scans by using bony landmarks. The distance between the center of the GEJ contour on the simulation scan and the mean location of GEJ centers on subsequent scans was used to assess changes in GEJ location between fractions

SUBMITTER: Wang J 

PROVIDER: S-EPMC3923625 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature