Proton beam therapy and concurrent chemotherapy for esophageal cancer.

ABSTRACT:

Purpose

Proton beam therapy (PBT) is a promising modality for the management of thoracic malignancies. We report our preliminary experience of treating esophageal cancer patients with concurrent chemotherapy (CChT) and PBT (CChT/PBT) at MD Anderson Cancer Center.

Methods and materials

This is an analysis of 62 esophageal cancer patients enrolled on a prospective study evaluating normal tissue toxicity from CChT/PBT from 2006 to 2010. Patients were treated with passive scattering PBT with two- or three-field beam arrangement using 180 to 250 MV protons. We used the Kaplan-Meier method to assess time-to-event outcomes and compared the distributions between groups using the log-rank test.

Results

The median follow-up time was 20.1 months for survivors. The median age was

SUBMITTER: Lin SH 

PROVIDER: S-EPMC3923631 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature