Soft matrix is a natural stimulator for cellular invasiveness.
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ABSTRACT:
SUBMITTER: Gu Z
PROVIDER: S-EPMC3923638 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Soft matrix is a natural stimulator for cellular invasiveness.
Gu Zhizhan Z Liu Fei F Tonkova Elina A EA Lee Soo Young SY Tschumperlin Daniel J DJ Brenner Michael B MB
Molecular biology of the cell 20131211 4
Directional mesenchymal cell invasion in vivo is understood to be a stimulated event and to be regulated by cytokines, chemokines, and types of extracellular matrix (ECM). Instead, by focusing on the cellular response to ECM stiffness, we found that soft ECM (low stiffness) itself is sufficient to prevent stable cell-to-cell adherens junction formation, up-regulate matrix metalloproteinase (MMP) secretion, promote MMP activity, and induce invadosome-like protrusion (ILP) formation. Consistently, ...[more]
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