SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.

ABSTRACT: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein contributing to genome stability via repair of DNA lesions via the base excision repair pathway. It also plays a role in gene expression regulation and RNA metabolism. Another, poorly characterized function is its ability to bind to negative calcium responsive elements (nCaRE) of some gene promoters. The presence of many functional nCaRE sequences regulating gene transcription can be envisioned, given their conservation within ALU repeats. To look for functional nCaRE sequences within the human genome, we performed bioinformatic analyses and identified 57 genes potentially regulated by APE1. We focused on sirtuin-1 (SIRT1) deacetylase due to its involvement in cell stress, including senescence, apoptosis, and tumorige

SUBMITTER: Antoniali G 

PROVIDER: S-EPMC3923644 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature