A network characteristic that correlates environmental and genetic robustness.

ABSTRACT: As scientific advances in perturbing biological systems and technological advances in data acquisition allow the large-scale quantitative analysis of biological function, the robustness of organisms to both transient environmental stresses and inter-generational genetic changes is a fundamental impediment to the identifiability of mathematical models of these functions. An approach to overcoming this impediment is to reduce the space of possible models to take into account both types of robustness. However, the relationship between the two is still controversial. This work uncovers a network characteristic, transient responsiveness, for a specific function that correlates environmental imperturbability and genetic robustness. We test this characteristic extensively for dynamic networks of

SUBMITTER: Shreif Z 

PROVIDER: S-EPMC3923666 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature