Chronic malaria revealed by a new fluorescence pattern on the antinuclear autoantibodies test.

ABSTRACT:

Background

Several clinical forms of malaria such as chronic carriage, gestational malaria or hyper-reactive malarial splenomegaly may follow a cryptic evolution with afebrile chronic fatigue sometimes accompanied by anemia and/or splenomegaly. Conventional parasitological tests are often negative or not performed, and severe complications may occur. Extensive explorations of these conditions often include the search for antinuclear autoantibodies (ANA).

Methods

We analysed fluorescence patterns in the ANA test in patients with either chronic cryptic or acute symptomatic malaria, then conducted a one-year prospective study at a single hospital on all available sera drawn for ANA detections. We then identified autoantibodies differentially expressed in malaria patients and in

SUBMITTER: Hommel B 

PROVIDER: S-EPMC3923801 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature