Assessment of unconstrained cerebrovascular reactivity marker for large age-range FMRI studies.

ABSTRACT: Breath hold (BH), a commonly used task to measure cerebrovascular reactivity (CVR) in fMRI studies varies in outcome among individuals due to subject-physiology and/or BH-inspiration/expiration differences (i.e., performance). In prior age-related fMRI studies, smaller task-related BOLD response variability is observed among younger than older individuals. Also, a linear CVR versus task relationship exists in younger individuals which maybe useful to test the accuracy of CVR responses in older groups. Hence we hypothesized that subject-related physiological and/or BH differences, if present, may compromise CVR versus task linearity in older individuals. To test the hypothesis, empirical BH versus task relationships from motor and cognitive areas were obtained in younger (mean age = 26 year

SUBMITTER: Kannurpatti SS 

PROVIDER: S-EPMC3923811 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature