Late multiple organ surge in interferon-regulated target genes characterizes staphylococcal enterotoxin B lethality.

ABSTRACT:

Background

Bacterial superantigens are virulence factors that cause toxic shock syndrome. Here, the genome-wide, temporal response of mice to lethal intranasal staphylococcal enterotoxin B (SEB) challenge was investigated in six tissues.

Results

The earliest responses and largest number of affected genes occurred in peripheral blood mononuclear cells (PBMC), spleen, and lung tissues with the highest content of both T-cells and monocyte/macrophages, the direct cellular targets of SEB. In contrast, the response of liver, kidney, and heart was delayed and involved fewer genes, but revealed a dominant genetic program that was seen in all 6 tissues. Many of the 85 uniquely annotated transcripts participating in this shared genomic response have not been previously linked to SEB.

SUBMITTER: Ferreyra GA 

PROVIDER: S-EPMC3923834 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature