Computational characterization of modes of transcriptional regulation of nuclear receptor genes.

ABSTRACT:

Background

Nuclear receptors are a large structural class of transcription factors that act with their co-regulators and repressors to maintain a variety of biological and physiological processes such as metabolism, development and reproduction. They are activated through the binding of small ligands, which can be replaced by drug molecules, making nuclear receptors promising drug targets. Transcriptional regulation of the genes that encode them is central to gaining a deeper understanding of the diversity of their biochemical and biophysical roles and their role in disease and therapy. Even though they share evolutionary history, nuclear receptor genes have fundamentally different expression patterns, ranging from ubiquitously expressed to tissue-specific and spatiotemporally comp

SUBMITTER: Sharma Y 

PROVIDER: S-EPMC3923872 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature