Peripheral venous congestion causes inflammation, neurohormonal, and endothelial cell activation.

ABSTRACT:

Aims

Volume overload and venous congestion are typically viewed as a consequence of advanced and of acute heart failure (HF) and renal failure (RF) although it is possible that hypervolaemia itself might be a critical intermediate in the pathophysiology of these diseases. This study aimed at elucidating whether peripheral venous congestion is sufficient to promote changes in inflammatory, neurohormonal, and endothelial phenotype similar to those observed in HF and RF.

Methods

To experimentally model peripheral venous congestion, we developed a new method (so-called venous stress test) and applied the methodology on 24 healthy subjects (14 men, age 35 ± 2 years). Venous arm pressure was increased to ∼30 mmHg above the baseline level by inflating a tourniquet cuff around the d

SUBMITTER: Colombo PC 

PROVIDER: S-EPMC3924182 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature