Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence.

ABSTRACT:

Background

Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind. MicroRNAs simultaneously target many transcripts and fine-tune the expression of genes through cooperative/combinatorial targeting. Therefore, they have a large regulatory potential that could widely impact development and progression of diseases, as well as contribute unpredicted collateral effects due to their natural, pathophysiological, or treatment-induced modulation. We support the viewpoint that whole mirnome-transcriptome interaction analysis is required to better understand the mechanisms and potential consequences of miRNA regulat

SUBMITTER: Nunez YO 

PROVIDER: S-EPMC3924350 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature