Global expression profiling reveals genetic programs underlying the developmental divergence between mouse and human embryogenesis.

ABSTRACT:

Background

Mouse has served as an excellent model for studying human development and diseases due to its similarity to human. Advances in transgenic and knockout studies in mouse have dramatically strengthened the use of this model and significantly improved our understanding of gene function during development in the past few decades. More recently, global gene expression analyses have revealed novel features in early embryogenesis up to gastrulation stages and have indeed provided molecular evidence supporting the conservation in early development in human and mouse. On the other hand, little information is known about the gene regulatory networks governing the subsequent organogenesis. Importantly, mouse and human development diverges during organogenesis. For instance, the mous

SUBMITTER: Xue L 

PROVIDER: S-EPMC3924405 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature