Abnormal brain activity during a reward and loss task in opiate-dependent patients receiving methadone maintenance therapy.

ABSTRACT: A core feature of human drug dependency is persistence in seeking and using drugs at the expense of other life goals. It has been hypothesized that addiction is associated with overvaluation of drug-related rewards and undervaluation of natural, nondrug-related rewards. Humans additionally tend to persist in using drugs despite adverse consequences. This suggests that the processing of both rewarding and aversive information may be abnormal in addictions. We used fMRI to examine neural responses to reward and loss events in opiate-dependent patients receiving methadone maintenance treatment (MMT, n=30) and healthy controls (n=23) using nondrug-related stimuli. Half of the patients were scanned after/before daily methadone intake (ADM/BDM patient groups). During reward trials, patients as a

SUBMITTER: Gradin VB 

PROVIDER: S-EPMC3924523 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature