Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia.

ABSTRACT: We previously reported linkage of schizophrenia and schizoaffective disorder to 13q32-34 in the European descent Afrikaner population from South Africa. The nature of genetic variation underlying linkage peaks in psychiatric disorders remains largely unknown and both rare and common variants may be contributing. Here, we examine the contribution of common variants located under the 13q32-34 linkage region. We used densely spaced SNPs to fine map the linkage peak region using both a discovery sample of 415 families and a meta-analysis incorporating two additional replication family samples. In a second phase of the study, we use one family-based data set with 237 families and independent case-control data sets for fine mapping of the common variant association signal using HapMap SNPs. We r

SUBMITTER: Rodriguez-Murillo L 

PROVIDER: S-EPMC3924527 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature