SPOP mutations in prostate cancer across demographically diverse patient cohorts.

ABSTRACT:

Background

Recurrent mutations in the Speckle-Type POZ Protein (SPOP) gene occur in up to 15% of prostate cancers. However, the frequency and features of cancers with these mutations across different populations is unknown.

Objective

To investigate SPOP mutations across diverse cohorts and validate a series of assays employing high-resolution melting (HRM) analysis and Sanger sequencing for mutational analysis of formalin-fixed paraffin-embedded material.

Design setting and participants

720 prostate cancer samples from six international cohorts spanning Caucasian, African American, and Asian patients, including both prostate-specific antigen-screened and unscreened populations, were screened for their SPOP mutation status. Status of SPOP was correlated to molecular fe

SUBMITTER: Blattner M 

PROVIDER: S-EPMC3924544 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature