The liver diseases of lipodystrophy: the long-term effect of leptin treatment.

ABSTRACT:

Background & aims

Lipodystrophies are hypoleptinemic conditions characterized by fat loss, severe insulin resistance, hypertriglyceridemia, and ectopic fat accumulation. Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are also features of this condition. We studied the spectrum of liver disease in lipodystrophy and the effects of leptin replacement.

Methods

This was an open-label, prospective study of leptin therapy in patients with inherited and acquired lipodystrophy at the National Institutes of Health. Liver biopsies were performed at baseline (N=50) and after leptin replacement (N=27). NASH activity was assessed using the NASH Clinical Research Network (CRN) scoring system. Fasting blood glucose, triglyceride, hemoglobin A1c and liver enzymes were m

SUBMITTER: Safar Zadeh E 

PROVIDER: S-EPMC3924897 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature