Accurate prediction of drug-induced liver injury using stem cell-derived populations.

ABSTRACT: Despite major progress in the knowledge and management of human liver injury, there are millions of people suffering from chronic liver disease. Currently, the only cure for end-stage liver disease is orthotopic liver transplantation; however, this approach is severely limited by organ donation. Alternative approaches to restoring liver function have therefore been pursued, including the use of somatic and stem cell populations. Although such approaches are essential in developing scalable treatments, there is also an imperative to develop predictive human systems that more effectively study and/or prevent the onset of liver disease and decompensated organ function. We used a renewable human stem cell resource, from defined genetic backgrounds, and drove them through developmental intermed

SUBMITTER: Szkolnicka D 

PROVIDER: S-EPMC3925059 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature