Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.

ABSTRACT:

Aim

To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities.

Methods

A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline, Elsevier Science, Springer Link, Cochrane Library database, China biology medical literature database (CBM),China National Knowledge Infrastructure (CNKI),VIP,and Chinese literature database(Wang fang). A total of 1596 patients with cervical cancer and 2048 controls from the 12 studies on the relationship between gene polymorphism of HLA-DRB l and cervical cancer were performed and data were analyzed and processed using Review Manager 5.0 and Stata 11.0.

Results

Among the 13 family alleles, two (DRB1*03 and DRB1

SUBMITTER: Wei LZ 

PROVIDER: S-EPMC3925111 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature