A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

ABSTRACT: Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b(+) DCs expressing OX40L. GM-CSF-driven allerg

SUBMITTER: Llop-Guevara A 

PROVIDER: S-EPMC3925157 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature