Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review.

ABSTRACT:

Introduction

Acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (GH) and subsequently insulin - like growth factor 1. Although cardiovascular diseases remains the most common cause of mortality among acromegalic patients, increased prevalence of malignant and benign neoplasms remains a matter of debate. The aim of this study is to evaluate the risk of thyroid nodular disease (TND) and thyroid cancer in patients with acromegaly.

Materials and methods

PubMed, Cochrane Library, Scopus, Cinahl, Academic Search Complete, Web of Knowledge, PubMed Central, PubMed Central Canada and Clinical Key databases were searched to identify studies containing. Random-effects model was used to calculate pooled odds ratios and risk ratios of TND in ac

SUBMITTER: Wolinski K 

PROVIDER: S-EPMC3925168 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature