Vascular deposition patterns for nanoparticles in an inflamed patient-specific arterial tree.

ABSTRACT: Inflammation, a precursor to many diseases including cancer and atherosclerosis, induces differential surface expression of specific vascular molecules. Blood-borne nanoparticles (NPs), loaded with therapeutic and imaging agents, can recognize and use these molecules as vascular docking sites. Here, a computational model is developed within the isogeometric analysis framework to understand and predict the vascular deposition of NPs within an inflamed arterial tree. The NPs have a diameter ranging from 0.1 to 2.0 μm and are decorated with antibodies directed toward three endothelial adhesion molecules, namely intravascular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin, whose surface density depends on the local wall shear stress. Results indic

SUBMITTER: Hossain SS 

PROVIDER: S-EPMC3925196 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature