Role of nanostructured gold surfaces on monocyte activation and Staphylococcus epidermidis biofilm formation.

ABSTRACT: The role of material surface properties in the direct interaction with bacteria and the indirect route via host defense cells is not fully understood. Recently, it was suggested that nanostructured implant surfaces possess antimicrobial properties. In the current study, the adhesion and biofilm formation of Staphylococcus epidermidis and human monocyte adhesion and activation were studied separately and in coculture in different in vitro models using smooth gold and well-defined nanostructured gold surfaces. Two polystyrene surfaces were used as controls in the monocyte experiments. Fluorescent viability staining demonstrated a reduction in the viability of S. epidermidis close to the nanostructured gold surface, whereas the smooth gold correlated with more live biofilm. The results were s

SUBMITTER: Svensson S 

PROVIDER: S-EPMC3925225 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature