Identification of a novel Parkinson's disease locus via stratified genome-wide association study.

ABSTRACT:

Background

Parkinson's disease (PD) is complex and heterogeneous. The numerous susceptibility loci that have been identified reaffirm the complexity of PD but do not fully explain it; e.g., it is not known if any given PD susceptibility gene is associated with all PD or a disease subtype. We also suspect that important disease genes may have escaped detection because of this heterogeneity. We used presence/absence of family history to subdivide the cases and performed genome-wide association studies (GWAS) in Sporadic-PD and Familial-PD separately. The aim was to uncover new genes and gain insight into the genetic architecture of PD.

Results

Employing GWAS on the NeuroGenetics Research Consortium (NGRC) dataset stratified by family history (1565 Sporadic-PD, 435 Familial-PD,

SUBMITTER: Hill-Burns EM 

PROVIDER: S-EPMC3925254 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature