Testing personalized medicine: patient and physician expectations of next-generation genomic sequencing in late-stage cancer care.

ABSTRACT: Developments in genomics, including next-generation sequencing technologies, are expected to enable a more personalized approach to clinical care, with improved risk stratification and treatment selection. In oncology, personalized medicine is particularly advanced and increasingly used to identify oncogenic variants in tumor tissue that predict responsiveness to specific drugs. Yet, the translational research needed to validate these technologies will be conducted in patients with late-stage cancer and is expected to produce results of variable clinical significance and incidentally identify genetic risks. To explore the experiential context in which much of personalized cancer care will be developed and evaluated, we conducted a qualitative interview study alongside a pilot feasibility s

SUBMITTER: Miller FA 

PROVIDER: S-EPMC3925281 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature