Small molecule inhibitors of anthrax lethal factor toxin.

ABSTRACT: This manuscript describes the preparation of new small molecule inhibitors of Bacillus anthracis lethal factor. Our starting point was the symmetrical, bis-quinolinyl compound 1 (NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.

SUBMITTER: Williams JD 

PROVIDER: S-EPMC3925373 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature