Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.

ABSTRACT: Analysis of microbiota in various biological and environmental samples under a variety of conditions has recently become more practical due to remarkable advances in next-generation sequencing. Changes leading to specific biological states including some of the more complex diseases can now be characterized with relative ease. It is known that gut microbiota is involved in the pathogenesis of inflammatory bowel disease (IBD), mainly Crohn's disease and ulcerative colitis, exhibiting symptoms in the gastrointestinal tract. Recent studies also showed increased frequency of oral manifestations among IBD patients, indicating aberrations in the oral microbiota. Based on these observations, we analyzed the composition of salivary microbiota of 35 IBD patients by 454 pyrosequencing of the bacteri

SUBMITTER: Said HS 

PROVIDER: S-EPMC3925391 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature